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The main drawback of dyes is their moderate selectivity for proteins.
Several compounds exhibited high potency and moderate selectivity for the ERβ receptor.
Several compounds are determined to have a high or moderate selectivity for mutant over wild-type kinase.
The synthesized DDR membrane exhibits a very high selectivity for CO2 and a moderate selectivity for N2 over CH4 with good permeances.
In the binding experiments at cloned hm1 5, the presence of the 2-methylimidazole/2-methyl-3-alkylimidazolium moiety in place of the pyrrolidine ring revealed, in derivatives 8a, 8b, and 9c, a moderate selectivity for some receptor subtypes.
The contorted ladder-like structure in polymers of intrinsic microporosity, specifically PIM-1 possesses high permeability but with moderate selectivity for O2/N2, CO2/N2 and CO2/CH4 separation.
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Currently, immune-based approached are most commonly applied, although moderate selectivity of antibodies represents a significant problem.
The most active analogue, 7d, displayed improved dual anthelmintic activity over 7-keto-sempervirol (IC50 ≈ 6 μM for larval blood flukes; IC50 ≈ 3 μM for juvenile liver flukes) and moderate selectivity (SI ≈ 4 5 for blood flukes, 8 13 for liver flukes compared to HepG2 and MDBK cells, respectively).
Among them, all were moderate selectivity toward leukemia cancer except for 4 exhibited distinctive selectivity of CNS and renal cancer with 7.403 and 6.475.
The calculated values also reveal that the nanocomposite membrane exhibits moderate selectivity towards all cations and that for the same concentration, the selectivity of the investigated carbonate membrane is comparatively more towards K+ ions as selectivity is proportional to counter-ion transport number, as suggested by the values given in the table.
Dyes' main drawback is their moderate selectivity during protein-binding.
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