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However, Ct-values ranged from 18 to 26, corresponding to low to moderate sample inhibition up to about 2.5 decadic logarithmic steps.
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Most assays can accommodate only moderate sample throughput.
One limitation of our study is its moderate sample size.
Dynamic marginal structural models lack precision at moderate sample sizes.
The essential oil showed strong activity (inhibition zone >20 mm), moderate activity (inhibition zone <20 12 mm), and no inhibition (zone <12 mm).
Compounds 483 485 exhibited moderate cytotoxicity inhibition with hFXR transactivation (IC50 3.9, 1.5, 2.5 µM).
Furthermore, a moderate growth inhibition was found for compound classes of indoles and 1H-pyrazoles.
Most of the tested compounds acted moderate XO inhibition with IC50 values in the micromolar rang.
We identified compound 12c as a highly potent GnRH antagonist with moderate CYP inhibition.
Compounds derived from N-benzylpiperidine and N-substituted purines showed moderate acetylcholinesterase inhibition.
Three SVM virtual hits of the same novel scaffold were experimentally tested, one of which showed moderate Src inhibition rate.
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