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In studies of high and moderate quality that reported the absence of petechiae as a risk factor, S. pneumoniae was also a prognostic factor of importance.
We found five studies of moderate quality that offer some support for the use of chair interventions to improve musculo-skeletal pain or discomfort in workers who sit for prolonged periods.
There is evidence of moderate quality that these treatments reduce pain in knee OA.
There is evidence of moderate quality that transcutaneous electrical nerve stimulation [TENS], low-level laser therapy and acupuncture reduce pain.
There is evidence of moderate quality that psychoeducation, including patient education and self-management programmes improve psychological outcomes, e.g., scales of psychological disability, mental functioning, self-efficacy or depressive symptoms.
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28 36 48 68 There was one prospective study, of low to moderate methodological quality, that reported an adjusted estimate for prolonged labour, the result of which was concordant with the meta-analysis (AOR=2.40, 95% CI 1.40 to 2.80).
Four trials (2407 participants) found moderate quality evidence that would be consistent with no effect or a harmful effect on malaria incidence (RR 1.04 (0.94, 1.14)).
22 24 28 Based on moderate quality evidence that included meta-analysis of two studies with over 2500 patients, 22 28 the mean total consultation time in the nurse practitioner group was 4.1 min longer per patient (95% CI 3.7 to 4.5; p<0.0001).
They also concluded that there is moderate quality evidence that children given IPT were less likely to have moderately severe anaemia at follow-up (Hb < 8 g/dL) compared to placebo (Risk ratio (RR) 0.71, 95% confidence interval (CI) 0.52 to 0.98).
Our results show that there is moderate quality evidence that IPT did not have an effect on death or hospital admissions at six months; and anaemia at 12 weeks; and that the mean change in Hb from baseline to 12 weeks was slightly higher amongst children receiving IPT.
Another review concluded that there was moderate quality evidence that exercises and mobilisations commonly used by physiotherapists were effective[ 13], but this was based on just three small trials, which reported short-term outcomes only, did not perform intention to treat analyses, and did not have blinding of outcome assessment.
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