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[59] Overall, most trials in this review included measures to reduce bias following randomization and were of moderate quality in reporting important outcomes including mortality, barotrauma, paralysis, and dialysis (see Table 5).
Nor can the quality of studies be sufficient reason for this difference, although stratification by study quality did reveal larger effect estimates in methodologically good studies than in those with moderate quality in Europe.
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We investigated the impact of BG traffic on the LQI of two different links, denoted Link 1 and Link 2, which offered good and moderate quality, respectively, in the absence of BG traffic.
There were ten high quality studies and thirteen moderate quality studies in our meta-analysis.
We included high or moderate quality studies in the meta-analysis.
Within the first month post-MDA, the prevalence of parasitaemia was much lower in three non-randomized controlled studies from Kenya and India in the 1950s (moderate quality evidence) and in three uncontrolled before-and-after studies conducted between 1954 and 1961 (low quality evidence).
In young children (aged 6 to 72 months) there were fewer deaths following rectal artesunate than with placebo (RR 0.74; 95% CI 0.59 to 0.93; one trial; 8050 participants; moderate quality evidence), while in older children and adults there were more deaths in those given rectal artesunate (RR 2.21; 95% CI 1.18 to 4.15; one trial; 4018 participants; low quality evidence).
Overall Table 3 suggests a moderate quality of evidence in this field.
More than half of 31 included systematic reviews were assessed as moderate quality using AMSTAR in pharmacist health intervention [ 3].
On the other hand, when filtering strategies are of moderate quality, small erosions in their performance can quickly impact the curation efficiency.
In young children rectal artesunate probably reduces the risk of death by 26% (moderate quality evidence) while in older children and adults rectal artesunate may increase risk of death (low quality evidence).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com