On the other hand, 90% ethanolic extract showed a moderate potency on the ovarian cancer (COAV) and MCF-7 cells having an IC50 of 104.6 μ g/mL each.
We originally recognized that the pyrazolopyrimidine class of kinase inhibitors possessed moderate potency for IGF1R during a high throughput screen of our compound repository [ 20].
Although detailed analysis of its acetyltransferase target or its mode of action has not been done, it appears to inhibit acetyltransferase(s) with moderate potency (IC50 of 25 μM).
In efforts to improve their oral bioavailability, replacement of the amidine group with methyl amidrazone gives compounds of moderate potency (14, IC50=0.028 μM).
Some compounds (8, 9, 10, 43 and 44) exhibited preference for the α-isoform, but they were of moderate potency.
The furan derivative is a carcinogen of moderate potency; however, it is abundant in heat-processed foods.
Both compounds showed moderate potency against procyclic and bloodstream forms of T. brucei (EC50 of 1.3 7.0 μM) but somewhat improved potency against T. cruzi trypomastigotes and amastigotes (less than 1 μM EC50 and EC95).
The compound has showed good selectivity towards FLT3 kinase, associated with a moderate potency, with an IC50 value of 1.74 μM.
High vapor pressure, ultrafast duration, and moderate potency are the main characteristics of this agent [ 51].
The 2-pyridyl carboxamide 56 gives moderate potency with an IC50 value of 278 n m.
