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The effect of memantine was consistently significant for ADL in moderately severe to severe patients and was not significant in mild to moderate patients.
Of these, approximately 25% of mild patients and approximately 10% of moderate patients were amyloid negative and, as a group, did not exhibit clinical progression typical of AD.
Results indicated that A.D. patients showed greatest impairment on pattern 7 (deficits in P, DI, and CI), reflecting late-stage gesture production, with a greater frequency of moderate patients exhibiting each apraxic pattern.
Results indicated that the moderate patients performed less accurately than mild and non-impaired patients, and that across all groups, the imitation conditions were performed less accurately than pantomime, relative to controls.
also improved over 10 years, they still had significantly lower QOL, and higher pain scores than the mild or moderate patients.
For moderate patients to be considered, the trials in mild to moderate patients must be included in the data synthesis.
Similar(36)
Limitations of our study are related to the retrospective study design and moderate patient numbers.
Pain on internal rotation was also assessed and recorded as mild ("patient states that it is painful"), moderate ("patient winces"), or severe ("patient withdraws").
The majority of mild-moderate patients are seen primarily by primary care practices.
However, there is no consensus on the cardiovascular benefits of CPAP therapy in mild-moderate patients.
However, only 12.5% of mild-to-moderate patients (baseline MMSE ≥14) showed such decline.
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