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The compound was synthesized in high purity, as suggested by nuclear magnetic resonance analysis, and in moderate overall yield.
Reductive amination between propargyl amine and methyl 6-formylnicotinate using sodium triacetoxyborohydride followed by basic hydrolysis of the methyl ester groups provided the desired ligand, 3, in moderate overall yield (55%) following isolation and purification.
Similar(58)
A five-steps straightforward convergent synthesis of the phosphane oxide derivatives in moderate overall yields has been proposed.
Solid-phase Evans' asymmetric alkylation on 23-derived N-acylimide resin and following lithium hydroperoxide-mediated chemoselective hydrolysis afforded the corresponding α-branched carboxylic acids in desired high stereoselectivities (up to 97% ee) and moderate to good overall yield (up to 70%, for 3 steps), which were comparable to those of the conventional solution-phase methods.
d-Allose (94%% overall yield), d-xylose (100%% overall yield) and d-mannose (only moderate rel.
The overall yield was up to 75%.
Although headache was moderate overall, mean duration was 10.0 h.
This route gives the better overall yield.
The overall yield starting from the membranes is approximately 2%.
More importantly, you will increase your overall yield.
The overall yield was 5.7% 6.4%.
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