GI adverse effects were similar, mild to moderate in overall severity, and transient.
The primary efficacy measure for the therapeutic response used by the researchers were the physician's global assessment (PGA) of overall severity, which was categorized into "clear," "almost clear," "mild," "moderate," and "severe".
For each case of generalized SA the degree of alopecia, seborrhoea and overall severity of skin lesions were given a score from 1 3 (mild, moderate, severe).
The photoevaluation was performed by a panel of experienced professionals according to a six-grade photographic scale 12 (devised by F Hoffmann-La Roche Ltd, BaSwitzerlandrating ratheg the overall severity of facial photodamage as grade 1 to 6 (mild, mild/moderate, moderate, moderate/severe, severe, very severe).
Compared with placebo, oral liarozole, 75 or 150 mg, once daily for 12 weeks, reduced the overall severity of ichthyosis and scaling, but not erythema or pruritus, and improved DLQI in patients with moderate or severe lamellar ichthyosis.
Most adverse events were of mild to moderate severity; overall, the most common adverse events in patients receiving CZP were headache, nasopharyngitis (in both studies), abdominal pain (PRECiSE 1), and cough (PRECiSE 2).
In the Japanese study, the majority of local reactions were mild or moderate in severity and overall were generally similar in incidence between the 2 age groups; exceptions were any redness, moderate redness, and moderate swelling, which were significantly lower (P < 0.05) in the 50 64 y age group compared with the ≥65 y age group (Fig. 2).
Over forty-two percent (42.7%) of the present sample had overall AIS head ratings indicative of moderate injury severity, 29.8% were rated as serious, 21.7% were rated as severe, and 5.8% were rated as critical.
Overall, most infections were mild or moderate in severity (Table 5); urinary tract infections were the most common.
The GSRS subscales and the GIQLI total score and subscales were able to differentiate among the clinical severity ratings of none, mild, moderate, and severe (overall Kruskall-Wallis test p < 0.001 for each subscale except GIQLI Social Function, Table 4).
