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eBraak stages IV to VI with moderate or frequent neuritic plaques.

Global cerebral senile plaque and neurofibrillary tangle load scores were obtained by summation of separate semi-quantitative density estimates of none, sparse, moderate or frequent (converted to 0-3 for statistical purposes) using standardized published templates [ 21].

Alzheimer's affected subjects had a Braak stage ranging from III to VI [ 12] with a Consortium to Establish a Registry for Alzheimer's Disease CERADD) neuritic plaque density of moderate or frequent [ 14].

Those in the misdiagnosed group received a primary clinical diagnosis of probable AD but did not meet the aforementioned neuropathological threshold for AD at autopsy (i.e., a moderate or frequent CERAD density score or a Braak neurofibrillary tangle stage of III-VI; n = 88).

In the paper of Clark et al., all the cases with no or sparse plaques at autopsy had SUVR values of less than 1,10, and all but one with moderate or frequent plaques at autopsy had SUVR values greater than 1,10.

Those in the accurately diagnosed group received a primary clinical diagnosis of probable AD based on NINDS-ADRDA criteria [ 26] and also received a neuropathological diagnosis/verification of AD per moderate or frequent density on the CERAD neuritic plaque density score [ 25] and a Braak neurofibrillary tangle stage of III-VI [ 27].

Similar(54)

The subjects with moderate or severe frequent pain (frequent or daily) within the last month were older than those without pain, were mostly female, complained about headaches and abdominal pain and showed significantly reduced ability to stand with closed eyes on one leg.

In the present study, sleep disorders co-existed, in tendency, with moderate or severe frequent pain.

This was justified because, according to the published methods for Study C, only a plaque score of 2 (moderate) or 3 (frequent) for thioflavin S was considered abnormal [ 30], and justified also according to the standardized analysis definitions for this study.

These FUS-positive NCIs when present, were moderate (or moderate-frequent) in numbers apart from case 7 where there were relatively few.

GERD patients, even those with moderate to severe symptoms or frequent symptoms, were as likely to consume tomato products and large portion meals as GERD-free controls and were even more likely to consume soft drinks and tea [odds ratio (OR) = 2.01 95% confidence interval (CI) 1.12-3.61; OR = 2.63 95% CI 1.24-5.59, respectively] and eat fried foods and high fat diet.

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