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The intensity of nausea was lower in the acupuncture cohort (n 140; 78% experienced no nausea, n = 24; 13% a little nausea, n = 14; 8% moderate nausea and n = 2; 1% much nausea) than in the standard care cohort (n = 32; 52% no nausea, n = 20; 32% a little, n 9; 15% moderate and n 1; 2% much) (p = 0.002).
Mild to moderate nausea and vomiting was dose related but readily controlled with antiemetics.
One nonobese volunteer experienced moderate nausea and vomiting 2 h after the 75-mg dose.
The most common non-haematological toxicities were mild to moderate nausea and vomiting.
In a study of patients with IBS, two patients in the probiotic group discontinued from the study because of adverse events (moderate nausea and severe exanthema).
Eleven patients were completely protected from vomiting; 9 had mild to moderate nausea and vomiting, but none severe enough to require alternative anti-emetic 'rescue'rescue
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Most of the reported toxicities started to develop after two to three courses Also, mild to moderate nausea (grade 1 2) and vomiting (grade 1 2) occurred frequently.
Discontinuations owing to AEs considered possibly or probably related to velaglucerase alfa occurred in 3 of 205 (1.5%) previously treated patients (mild blood pressure increase possibly related in two patients and moderate nausea probably related in one patient).
Two volunteers in the i.v. group withdrew from the study owing to AEs (moderate nausea, dizziness, agitation, pharynx dysesthesia, dyspnea, and a respiratory disorder) and withdrawal of consent, respectively, after receiving a single dose of Amgen filgrastim.
Moderate nausea was observed in 8 patients (26.67%), and vomiting occurred in 7 patients.
Both require titration to effective doses over a period of 2 4 weeks and are associated with mild to moderate nausea in almost half of those exposed on at least one occasion, particularly as therapy is initiated.
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