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At moderate mutation rates evolution leads to longer genomes with a higher diversity than at high mutation rates.
Instead, moderate mutation rates increase genetic diversity through increasing genome length and therewith enlarges evolutionary search space which in turn maximizes evolutionary efficacy.
Under moderate mutation rates, predators keep evolving towards the full evolutionary target, possibly diminishing the remains of prey more and more.
Under moderate mutation rates, spatial structuring of co-evolving populations benefits the information integration over evolutionary time in replicators [ 16- 18].
Therefore, moderate mutation rates allow for more degrees of freedom in exploring genotype space during the evolutionary trajectory, facilitating the emergence of solutions.
Because three mutations have also been observed occasionally among 17 Yfiler loci in DNA-confirmed father son pairs [Goedbloed et al. 2009], this notion also applies to conventional Y-STR sets such as Yfiler, which due to their moderate mutation rates in principle are more appropriate for paternity and kinship testing than RM Y-STRs.
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However, mtDNA markers are best suited for analyses of historical processes at larger geographic scales, as they can only provide information on long-term accumulated effects of female dispersal due to their moderate mutation rate and maternal mode of inheritance [ 8].
The initial decay occurs more rapidly for populations that reached the previous stationary state at moderate to high mutation rates than for those that were previously optimized at low mutation rates.
Panels B&C shows that the rank correlation does not suffer when sampled continuously, at least at moderate or large mutation rates.
When the recombination rate is moderate compared with mutation rate, the sequences may be decomposed into a few segments that have specific phylogenetic histories.
Interestingly, the FokI-dCas9 group exhibited moderate birth rates (18.2% and 17.6%) and mutation rates (66.6% and 33.3%).
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