Sentence examples for moderate mutation from inspiring English sources

Cx32V84I is a physicochemically moderate mutation that was found to cause CMTX disease [44] (see also Supplementary Table 2 at http://bioinfo.tau.ac.il/~sarel/GJ.html,) whereas Cx26V84L is a rare mutation associated to nonsindromic deafness [32].

At moderate mutation rates evolution leads to longer genomes with a higher diversity than at high mutation rates.

Instead, moderate mutation rates increase genetic diversity through increasing genome length and therewith enlarges evolutionary search space which in turn maximizes evolutionary efficacy.

Under moderate mutation rates, predators keep evolving towards the full evolutionary target, possibly diminishing the remains of prey more and more.

Under moderate mutation rates, spatial structuring of co-evolving populations benefits the information integration over evolutionary time in replicators [ 16- 18].

Therefore, moderate mutation rates allow for more degrees of freedom in exploring genotype space during the evolutionary trajectory, facilitating the emergence of solutions.

Notably, recent genome sequencing studies reported frequent mutations of ARID1A and PIK3CA genes and moderate mutations of PPP2R1A and KRAS in ovarian clear-cell carcinomas [ 51, 52] and frequent mutations of PTEN, CTNNB1, and KRAS in endometrioid cancer [ 53, 54].

Clinical severity might depend on the type of mutations present, such that severe loss-of-function mutations (e.g., truncating alleles) lead to severe disease, while more moderate mutations with residual protein function (e.g., hypomorphic missense changes) may give rise to milder phenotypes with later disease onset and possibly also slower progression.

Thus, the cybrid cell lines harbour mtDNA variations, which result in a spectrum of biochemical phenotypes (Tables 1 and 2) ranging from severe (Mtnd5/nd6 mutations), to moderate (Mtco1 mutations), to insignificant (Mttrpolymorphism).

The majority of variants within a given gene generally fall into one of these categories, although exceptions are being increasingly recognized; for example, the moderate penetrance mutation BRCA1 p.Arg1699Gln [ 10].

A woman with a moderate penetrance mutation in Grann et al (1998) gained 0.2 undiscounted QALYs from having both mastectomy and oophorectomy compared to 2.1 (Grann et al, 2000) and 2.6 (Grann et al, 2002) undiscounted QALYs in the revised models.