Sentence examples for moderate micromolar range from inspiring English sources
Evaluation against MAO identified several compounds that inhibited in the low to moderate micromolar range.
Most compounds showed moderate potencies in micromolar range, with the most promising analogue 6f showing active at submicromolar concentration against HT-1080 cellsr cells which was selected to investigate the antitumor mechanisms.
Herein we report on a novel class of 5- 2-hydroxybenzylidene) rhodanines as gyrase B inhibitors with activity in low micromolar range and moderate antibacterial activity.
This contrasts with the moderate sensitivity to free antigen (micromolar range) observed for the cyclic aliphatic and nonpolar COP.
An increase in the structural rigidity of the hydrophobic and poly-cyclic second antigen COP did not really improve this moderate IC50 sensitivity beyond the micromolar range.
Taken together, these data suggest that at the moderate MPDP+/1.2-MPDP concentrations (low micromolar range) that exist in vivo, intracellular autoxidation of MPDP+ would not be sufficient to generate damaging intracellular MPP+ concentrations.
Representative compounds tested using ITC were revealed to possess moderate binding affinity in the low micromolar range.
It was found that some of synthesized benzimidazole derivatives (7 of 22, 32%) possess strong virus-inhibiting activity against pandemic influenza virus (IC50's in low micromolar range) with quite moderate cytotoxicity (CC50 in the range of thousands micromoles).
These azole derivatives showed moderate inhibition against T. brucei and L. donovani in micromolar range IC50s.
Several compounds exhibited promising activities on different NaV channel isoforms in the medium micromolar range and some of the compounds showed also moderate isoform selectivities.
It showed an inversely U-shaped character in the micromolar range (maximum at 100 μM) and a second moderate rise of stimulated CGRP release in the millimolar range; only the latter involved the TRP channels, TRPV1 and TRPA1, whereas the former depended solely on nAChRs.
