Sentence examples for moderate knockdown of from inspiring English sources

These results indicate that moderate knockdown of AXL may be sufficient to reduce tumorigenicity.

These results demonstrate that moderate knockdown of either CDK11 or CK2 significantly impacts the growth and viability of TNBC tumors.

Of note, siRNA no. 4 only showed a moderate knockdown of FAT1 but still increased sensitivity towards TRAIL, thus suggesting an off-target effect.

Since overexpression of Sirt6 can attenuate oxidative stress-induced EC dysfunction and senescence, we tested if moderate knockdown of Sirt6 would mimic effects of oxidative stress.

Therefore, while moderate knockdown of the protein has no effect on cell growth, attempts to delete both alleles of the gene have so far been unsuccessful, resulting in either transfection failure or genetic rearrangements.

Our data demonstrate that TBG nanoencapsulation of anti-CDK11 or anti-CK2 siRNAs is a highly specific means of successfully delivering the drug to malignant cells in vivo, and moderate knockdown of either kinase resulted in significant therapeutic benefit.

Moderate ubiquitous RNAi knockdown of FKH with the armadillo driver leads to a slight decrease in larval size under fed conditions (Figure 1E).

Moreover, moderate cardiac-specific knockdown of integrin-linked kinase (ILK /integrin pathway-associated genes also prevented the decline in cardiac performance with age.

Knockdown of USP9x causes a moderate reduction in the level of AGS3.

Knockdown of TbMORN1 had a moderate inhibitory effect on cell growth in procyclic (the insect stage) T. brucei, but was lethal in the bloodstream stage parasite [12].

The null allele of Chd1 (Chd1 ) as well as pINT-H1 4M and pINT-H1 1M P-element insertion alleles (second and third chromosomes, respectively) that encompass a UAS-driven His1 hairpin transgene and produce moderate H1 knockdown under the control of Tubulin- or Act5C-GAL4 drivers were described elsewhere (Konev et al. 2007; Lu et al. 2009).