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Some antivirally active compounds also showed moderate inhibitory activity against RT.
These compounds showed moderate inhibitory activity against influenza A neuraminidase.
Most of synthesized compounds showed moderate inhibitory activity against cancer cells.
Biological testing confirmed moderate inhibitory activity of halogen-substituted saturated diazabicyclic small molecules towards thrombin.
Compound C12 showed moderate inhibitory activity against EGFRL858R/T790M/C797S (IC50 = 114 nM).
Natural -huperzine B (HupB), isolated from Chinese medicinal herb, displayed moderate inhibitory activity of acetylcholinesterase (AChE).
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Ky-14 showed moderate inhibitory activities against HDAC1 and HDAC4 compared with Ky-2 (Supplementary Table S1).
All the compounds showed inhibitory potencies, and 10 of these exhibited moderate inhibitory activities with IC50 values less than 10 μM.
In vitro cell growth inhibition assays indicated that compound 6m exhibited moderate inhibitory activities only against human hepatocellular carcinoma cells HepG2 with IC50 of 8.3 μM.
The preliminary results showed that most of the target compounds had moderate inhibitory activities and selectivities against root and stalk of monocotyledon and dicotyledon plants.
Some compounds exhibited moderate inhibitory activities against seven plant pathogens at 50 μg/mL in vitro, compounds 5g and 7c displayed nearly the same or higher fungicidal activities against some certain plant pathogens compared with the lead compound pyrimorph.
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milder inhibitory activity
modest inhibitory activity
moderate analgesic activity
moderate inhibitory enzyme
moderate insecticidal activity
moderate scavenging activity
moderate anticancer activity
moderate disease activity
moderate antioxidant activity
moderate geomagnetic activity
moderate antitumor activity
moderate inhibitory potency
moderate inhibitory effect
moderate inhibitory activities
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