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By contrast, SV5-WT induced very low cytokine responses, with the notable exception of moderate induction of RANTES.
We observed a very moderate induction of differentiation in control cells, when treated with cytarabine.
Expression of an active dFOXO mutant in S2 cells leads to a moderate induction of cabut expression, while refeeding in adult flies has a weak repressing effect [28].
In conclusion, vinculin-ΔEx20 displays strong head binding accompanied by a moderate induction of cell contacts and no dominant negative effect on cell motility/migration.
As expected, vehicle-treated HFD-fed mice showed a moderate induction of epididymal fat Emr1 and Tnf expressions, whereas the expression of Ccl2, encoding MCP-1, was already strongly increased (Fig 2B).
On the other hand, sc astressin2-B-injected CRF-OE mice showed a moderate induction of skin pigment during the first week post injection (Fig. 5I), but continued to lose hair similarly as the saline-treated mice (Fig. 5.E H, J).
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In addition, a clear induction of several genes involved in glucose metabolism (PGK1, LDHA, TPI1, and moderate induction levels of ALDOC, ENO1, ENO3 and PFKP; Fig. 1) was observed.
Adipocytes from HFD ctsk−/− mice showed a moderate induction (33%) of lipolysis after isoproterenol treatment, although this increase was not statistically significant compared to WT animals (Figure 3B, bottom panel).
Interestingly, although ATF4 showed a moderate induction, several of its downstream targets were strongly up-regulated, e.g. DDIT3, ATF3, CEBPB, CEBPG, CREB3L2 (1.7) and TRIB3 (6.7).
Expression from the Atg7 and Atg1 loci was still observed in the mutants; since these alleles had been previously characterized as genetic nulls, presumably truncated versions of wild-type transcripts were detected., Of the genes encoding members of the Atg1 kinase complex, Atg1, FIP200 and Atg101 showed a moderate induction, while the levels of Atg13 did not change.
Expression of these UPR components showed a moderate induction.
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