Sentence examples for moderate in vitro from inspiring English sources

These glucosides with cyclic diarylpolynoids demonstrated moderate in vitro inhibitory activity against SGLT2 in this series to date (IC50 = 59.5 103 nM).

Using primary human bronchial epithelial cells (HBECs) we demonstrate moderate in vitro cytocompatibility for all surface modifications; however, larger pores resulted in cellular aggregation.

We tested this in a much larger study and confirm a moderate in vitro augmentation of some NKT cell functions by lenalidomide, but find no impact on the NKT cell compartment of patients treated with lenalidomide, despite a consistently positive clinical response.

The resultant scaffolds exhibited a water uptake ratio of 229%, and moderate in vitro degradation rates of less than 5% in phosphate-buffered saline (PBS) and slightly more than 20% in trypsin-containing buffer, within 14 days.

In particular, compound 4I disclosed a moderate in vitro LOX inhibition with an IC50 = 100 μM whereas compounds 1I and 2II exhibited the best, albeit poor, activity as COX-1 inhibition (75% inhibition at 100 μM).

This discrepancy between high in vitro binding affinity, moderate in vitro activity, and low in vivo activity may reflect differences in pharmacodynamics (i.e., engaging signaling pathways) or pharmacokinetics (i.e., metabolic stability).

Though Dkk4 up-regulation by Eda in vivo was more moderate than in vitro [23], the results are consistent with that Eda as a likely upstream regulator of Dkk4.

Since the a1- α2 complex was able to bind to these sites with weak to moderate affinity in vitro, it is possible these sites may partially repress transcription on their own.

High plant density with moderate mineral concentrations in vitro increased curcumin/bisdemethoxycurcumin ratio to 17.5 ± 1.7 under low-input fertilizer.

All the new azoles showed moderate to excellent in vitro antifungal activity against most of the tested pathogenic fungi.

Lead compounds such as 35 and 43 have moderate to good in vitro potency and excellent selectivity against Notch.