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ES on primary end points was moderate in three of the active treatment groups and in two of the sham groups.
At study start, "fatigue", which was part of the core variables for the physicians' global assessment, was severe in two patients, moderate in three patients and mild in one patient.
Cytoplasmic inclusions within granule cells of the dentate gyrus were variable, being few or absent in eight patients, moderate in three patients, but numerous in four others (Fig. 2b, Table 1); the hippocampus was not available for investigation in the other case.
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Over ninety percent of the eyes (91.6 %) were noted to have vitreous inflammation, among which inflammation was described as moderate in four eyes (33.3 %) with the remaining seven (63.6 %) not quantifying the severity of the inflammation.
Within these 12 eyes, 10 (83.3 %) were noted to have anterior chamber inflammation, among which the inflammation was described as mild in one case (8.3 %) and moderate in four cases (33.3 %)—with the remaining seven (58.3 %) not quantifying severity.
Vascular disease was mild or absent in most patient and considered to be moderate in one.
Influenza A virus antigen staining in both medullary and cortical cells of the adrenal gland was moderate in one of 5 birds and mild in another.
The disease state was mild in four patients, moderate in five, and severe in eight patients.
Two-dimensional echocardiogram demonstrated severe disease in two, moderate in five, and mild in one.
The severity of hepatitis was mild in three patients and moderate in two patients.
The strength of association was moderate in five studies and weak in two studies.
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