Because it exhibits dose linearity [ 73] and does not accumulate in the body after repeat administration, pantoprazole can be used without dose adjustment in elderly patients and in those with renal impairment or failure, or moderate hepatic impairment [ 73- 76].
Hepatic failure secondary to viral hepatitis was the most frequent hepatic event in our analysis.
The Brussels score places renal, coagulation, cardiovascular, central nervous system, and hepatic failure into no organ dysfunction, mild, moderate, severe, or extreme organ dysfunction.
Moderate or severe liver disease was defined as cirrhosis with portal hypertension, or hepatic failure with coma or encephalopathy within the preceding 6 months.
Indication for MARS included 16 cases of fulminant hepatic failure, 21 cases of acute failure on cirrhosis, one intractable pruritus, eight moderate or severe acute liver failure (Bernuau criteria).
A case of acute pancreatitis following intravenous valproate administration has been reported, as well as a case of fulminant hepatic failure associated with hemorrhagic shock leading to death in 9-year-old patient with cerebellar syndrome and moderate mental retardation receiving intravenous valproate for the treatment of SE [ 80].
By Sunday, they said, he was slipping in and out of consciousness amid hepatic failure.
Both patients were older with mild to moderate hepatic impairment.
The types of organ failure were respiratory failure (70 patients), renal failure (8 patients), and hepatic failure (3 patients).
Subacute complication developed in 48.15% (hemodynamic failure 7.4%, hepatic failure 7.4%, HE 11.1%, stent thrombosis 22.2%).
