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In patients with marked restriction of exercise capacity or with symptoms at rest (mild to moderate heart failure), there is significant benefit from low doses of beta-blockers, renin-angiotensin system inhibitors, and inhibitors of aldosterone (a steroid hormone that regulates the balance of salt and water in the body).
We have designed the study to evaluate the effects of pitavastatin, a lipophilic statin, on Japanese patients with mild to moderate heart failure.
The purpose of this study was to test the safety, tolerability, and efficacy of MCC-135 in patients with mild to moderate heart failure.
A recent animal study investigating the outcome of oral probiotic administration in rats with moderate heart failure has produced encouraging results.
However, it was shown to decrease hospital admissions and overall mortality in patients with atrial fibrillation, and mild to moderate heart failure in the ATHENA trial [ 18].
The new extended GP role was developed to enable GPs to diagnose and manage patients with mild to moderate heart failure and patients with atrial fibrillation in primary care.
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The second group, scanned on scanner II, consisted of 10 consecutive patients with mitral regurgitation (10 men, age range 22 73 years, mean age 56.1 ± 15.9 years) and mild-moderate heart failure.
Mild-to-moderate heart failure after MI is also associated with increased mortality; 30-day mortality was 8% for patients with mild-to-moderate heart failure, compared with 2% for patients without (Hasdai et al. 2003).
2 8 Furthermore, primary ICD trials were conducted in outpatients with symptoms of stable mild-to-moderate heart failure.
Whereas most studies included patients with mild-to-moderate heart failure, another trial tested pentoxyphilline in a small NYHA IV patient cohort.
Data from over 60 000 MI patients enrolled in four trials of fibrinolytic therapy showed that 29% had mild-to-moderate heart failure (Hasdai et al. 2003).
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