The sample size was small to moderate for the four disease cohorts.
The methodological quality of the four comparable cohort and seven observational studies was good, and moderate for the two randomised control trials.
Based on studies by Chochinov and colleagues, 32 the severity of depressed mood or anhedonia needed to be at least moderate for the two weeks before the interview in order to reach the threshold for diagnosis.
The methodological quality of the four comparable cohort and seven observational studies was good and moderate for the two RCT (Table 1).> -wrap-foot> Note: Y – Yes, N – No, U- Unclear, N/A – Not applicable.
Furthermore, the two subscales self-reflectiveness and self-certainty showed low or moderate correlation for the three groups, indicating that they represent two different dimensions of cognitive insight.
There were moderate correlations for the three groups, which were higher for control subjects (r = -0.46, p < 0.01), and patients with retinopathy (r = -0.59, p < 0.01), and lower for patients with no retinopathy (r = 0.36, p < 0.05).
Lower level facilities achieved only low-to-moderate scores for the three parts, apart from two maternity homes on part A and one on parts B and C, and provided overall low quality of ENC.
Convergent validity agreement was moderate (range for r = 0.55, 0.67) for cluster B disorders rated with DSM-IV criteria, and discriminant validity was moderate for eight of the ten personality disorders.
The internal consistency for the overall COHIP-SF 19 score was excellent with a Chronbach's alpha of 0.81, good for the socio-emotional well-being subscale (0.74), and moderate for the other two subscales (0.56-0.59; Table 2).
This review on the diagnostic accuracy of the Whooley questions provides evidence of consistent high sensitivity and moderate specificity for the two questions across a range of settings among different populations.
