Sentence examples for moderate fold change from inspiring English sources
With the log2 fc ≥ 0.75 a moderate fold change filter was applied [ 37].
Genes were grouped according to their expression profiles by transforming the expression data into moderate fold change estimates using a variance stabilizing transformation [ 37].
Therefore, we chose not only highly over-expressed or down-regulated genes, but also genes with moderate fold change and genes, whose transcript abundance remained stable throughout the experiment.
A range of transcript abundance levels were included in the design of the panels, with the aim of mimicking, for example, transcripts with low abundance in the 'normal' state with a large increase in expression in the 'disease' states (e.g. ERCC-171) or transcripts of average abundance with a moderate fold change in the disease-state (e.g. ERCC-99) (Table 3).
In the first epigenomic profiling studies performed in major psychosis, Mill et al. found moderate fold changes in prefrontal cortex DNA methylation.
This matrix was used for differential expression analysis using DESeq (Anders and Huber, 2010) using per-condition dispersion estimates and variance stabilization to compute moderate fold changes.
Although the differentially-expressed genes do not pass the p<0.05 threshold after FDR adjustment for the 28,064 probe sets tested, likely due to their moderate fold changes, they do show statistically significant enrichment in several gene ontology categories (FDR-adjusted p<0.05; Figure 4A).
Furthermore, we select a subset of genes with large changes in expression comparing GeneBASE and GeneBASE-xhyb estimates, selected for large absolute log moderated fold-change values, described in Equation (4).
Our data show a moderate (-3.71 fold change) down-regulation of trout CXCR4.
There were 243 genes differentially expressed when comparing the two different exposure rates, with a moderate range of fold change between 0.3 and 3.9.
From the spread of the data for each strain, it can be estimated that a moderate two-fold change in expression level can be detected with ≥80% confidence in individual experiments.
