At necropsy, the liver was cirrhotic and microscopically showed moderate fatty change and hyaline Mallory bodies; spider angiomata, jaundice, ascites, and esophageal varices also were present.
It is evident by the presence of hepatic cords with moderate fatty change and few inflammatory cells, and absence of necrosis).
The histology of liver from FCA induced animals revealed moderate microvesicular fatty changes, with sinusoidal congestion and infiltration of mononuclear cells.
Twenty-seven patients had moderate or severe fatty change (22 treated, 5 untreated).
The architectural pattern of liver sections of reference and treatment groups showed repairing lobular pattern with a mild to moderate degree of fatty change, necrosis, and lymphocytes infiltration which could be compared to the normal control group.
The definite diagnosis of NASH was based on a histology showing moderate to gross macrovesicular fatty change with inflammation (lobular or portal), with or without Mallory bodies, fibrosis, or cirrhosis.
This liver also showed diffuse nuclear anisocytosis, moderate parenchymal inflammation and patchy fatty change (Fig. 7E).
Surprisingly, 28th day group showed moderate changes including fatty changes of hepatocytes and pyknosis of hepatocytic nuclei (Fig. 6f).
hepatic architecture: preserved, partial loss or complete loss, hydropic degeneration: absent, mild, moderate or marked, fatty changes: absent or present, central vein congestion: present or absent, Kupffer cell hyperplasia: absent or present, necrosis: absent or present, infiltration of portal tract by lymphocytes: absent or present.
Bilateral metastases in inguinal lymph nodes, massive pulmonary tumour embolization, hepatic fatty change, mild multifocal neutrophilic hepatitis, cystic ovaries, and moderate cystic endometrial hyperplasia were also detected.
In the liver section pretreated with 250 mg/kg MEDL a moderate damage to the liver's architecture was seen indicated by the presence of moderate steatosis with some fatty changes and mild leucocytes infiltration around the centrilobular region.
