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We also showed that patients with prior frequent exacerbations, as well as those with only one prior moderate exacerbation, are at increased risk of future exacerbation events.
A moderate exacerbation was defined as a worsening of daily symptoms that led a patient's clinician to prescribe systemic corticosteroids and/or antibiotics, but did not require hospitalisation.
We defined a moderate exacerbation as a worsening of daily symptoms that led a patient's physician to prescribe systemic corticosteroids, antibiotics, or both, without hospital admission.
A moderate exacerbation was defined as one requiring outpatient antibiotic and/or oral corticosteroid use, and a severe exacerbation was defined as one requiring hospitalisation.
A reduction of 15% in QoL for one month after a (moderate) exacerbation and 50% or 70% for a severe exacerbation (requiring hospitalisation) was assumed,[ 10- 13] or a relative ratio of 3.33 or 4.67.
We suggest that these transient increases in perfusion and metabolism in both non-exercised and exercised mdx groups reflect active cycles of degeneration/regeneration and a moderate exacerbation of muscle pathogenesis, respectively.
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Furthermore, the most recent meta-analysis provided inconsistent results regarding inpatients (COPD with severe exacerbations) and outpatients with mild to moderate exacerbations [51].
Outpatients were considered to have mild to moderate exacerbations.
Unless the report stated that most events fulfilled the criteria for severe exacerbations, we classified events defined by elements of both severe and moderate exacerbations as moderate exacerbations.
The present population consists of patients with mild to moderate exacerbations.
Thirty-seven per cent of patients had two or more moderate exacerbations and 2% had two or more severe exacerbations.
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