For proline, a compatible osmolyte [ 67], one 6-fold up-regulated UniTag with homology to a proline/betain transporter (STCa-24308) as well as moderate down- and up-regulation of two 26 bp tags representing a negative regulator for proline accumulation (proline dehydrogenase; STCa-8454, STCa-8455) were revealed.
The moderate down regulation of CXCR4 in LPS treated fish (table 1) and upregulation (>1.5 fold) in attIHNV infected fish (see additional file 1), together with the strong upregulation of C3aR in IHNV treated fish suggests a conservation of complement mediated functional responses in the hematopoietic head kidney.
Cooling towers are known for their efficiency in cooling industrial water streams from moderate down to nearly ambient temperatures.
This indicated that a moderate down regulation of the gene expression inhibited the growth.
We observed moderate down regulation of terms involved in oxidation processes, TCA enzymes, transmembrane transport, aldehyde, monocarboxylic acid and glutathione metabolisms, catabolic process of nitrogen compounds, heterocycle and nucleosides, and PKC signaling.
Cluster 4 contained 120 features down-regulated at all time points, with mild down-regulation early and moderate down-regulation observed at 24 and 48 h.
Nevertheless, the RNA profiling identified strong up-regulation of Bmp2 and Bmp4 and moderate down-regulation of Bmp7 mRNAs (File S4).
We found anterior placental site to be significantly associated with a moderate down-towards-birth pattern (FPC2) and with a U-shaped pattern (FPC3), combining the gradual decrease in counting time with a small increase in late gestation.
The group of lines amiRPPO23-7 and amiRPPO23-9 showed strong down-regulation of both the StuPPO2 and StuPPO3 genes, moderate down-regulation of the StuPPO4 gene, as well as similar RPPO and RBR values.
To test this hypothesis for the SNP dataset, we conducted regression by implementing a generalized linear model assuming a negative binomial distribution of the number of nucleotide changes per gene in five differential expression categories: strong down-regulation, moderate down-regulation, no change, moderate up-regulation, and strong up-regulation.
Since in vivo we found a decrease in PABPN1 expression with age in both normal aging and in OPMD, we studied whether at with a moderate down-regulation of PABPN1 myogenic defects can also be observed.
