Belayev, L., Liu, Y., Zhao, W., Busto, R. & Ginsberg, M. D. Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window.
Belayev, L., Liu, Y., Zhao, W., Busto, R. & Ginsberg, M.D. Human albumin therapy of acute ischemic stroke: Marked neuroprotective efficacy at moderate doses and with a broad therapeutic window.
To my great surprise a large and well-conducted study recently found the lowest mortality in the severely ill who had received low to moderate doses as compared with those who had taken no medicine or high doses.
Selectivity is evident at moderate doses (0.05%), with destruction of neurons in the tuberomammillary nucleus and non-cholinergic neurons in the basal forebrain and pontine tegmentum [29].
Rebuffé-Scrive et al 46 demonstrated a reduction in waist/hip ratio and abdominal lipoprotein lipase activity with moderate doses of testosterone in moderately obese middle-aged men.
In contrast to major concerns about severe side effects, re-irradiation with moderate doses of 30 40 Gy has been associated with acceptable toxicity [ 23- 26], if restricted target volumes were used and the interval to previous irradiation was >6 months.
Treatment with moderate doses of hydrocortisone increased capillary density and perfusion in patients with septic shock [28].
Treatment with moderate doses of hydrocortisone increased capillary density and perfusion in patients with septic shock [ 28].
Because of the known toxicity of high-dose IL-2 or high dose cyclophosphamide (CY) treatment, the goal of our experiments was to investigate the efficacy of chemoimmunotherapy with low or moderate doses of cyclophosphamide (CY) in combination with low or moderate doses of IL-2 with or without adoptively transferred LAK cells.
Systemic delivery into many cells in adult organisms can be accomplished by using covalent conjugates of Morpholino oligos with cell-penetrating peptides, and, while toxicity has been associated with moderate doses of the peptide conjugates, they have been used in vivo for effective oligo delivery at doses below those causing observed toxicity.
