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These findings suggest some commonalities in the subjective effects of moderate doses of alcohol and AMPH in nonproblem drinkers.
Bond V, Franks BD, Howley ET. Effects of small and moderate doses of alcohol on submaximal cardiorespiratory function, perceived exertion and endurance performance in abstainers and moderate drinkers.
And some pain experts believe that there are patients who function well on moderate doses of opioids and do not require more.
Yet little is known about how more complex interactions between cortical regions are affected even at moderate doses of alcohol.
One of the most robust and readily measurable effects of moderate doses of ethanol on zebrafish behavior is locomotor hyperactivity.
A researcher at Johns Hopkins University in the USA gave monkeys and baboons three moderate doses of what he claimed to be MDMA, and found severe impacts on levels of dopamine (a neurotransmitter) in the animals.
Dr. Auwerx's study complements one published this month by Dr. David Sinclair of the Harvard Medical School, who found that much more moderate doses of resveratrol protected mice from the metabolic effects of a high-calorie diet.
Following the chronic administration of moderate doses of antipsychotic drugs, tolerance to the effects of a haloperidol challenge dose is generally seen in the striatum and olfactory tubercle but not in the frontal cortex6 8.
Although moderate doses of ethanol slowdown the neurovascular coupling, the functions of the primary sensorimotor and the visual system remain intact.
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They included nine trials of low-to-moderate doses of corticosteroids (<1,000 mg per day of hydrocortisone or equivalent).
Five randomized trials investigated the effects of low-to-moderate doses of corticosteroids when initiated within the 24 hours of onset of severe sepsis [25, 42 46].
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