Treatment of T cells with ionomycin induced a moderate dose-dependent increase in F-actin.
CYP6Z8 transcription was significantly induced by all compounds (2.0 3.4-fold 2.0 3.4-foldrate dose-dependent effect.
S. pinnata extract also caused a moderate dose-dependent inhibition of nitric oxide with an IC50 (Table 1) of 24.48 ± 2.31 μg/ml (figure 4).
The matter of fact is that ox-Lp(a) might cause more pronounced stimulation of superoxide production, whereas native Lp(a) itself caused a moderate, dose-dependent stimulation of superoxide production.
Nevertheless, studies in healthy human subjects have shown that nitrite causes marked venodilatation and moderate dose-dependent arteriolar dilatation, and these effects are augmented by hypoxia or exercise in healthy subjects (Cosby et al., 2003; Maher et al., 2008).
In mice, daily subcutaneous injection of SAHA led to moderate dose-dependent reductions in paw swelling, and production of IL-6 and IL-1β, but minimally reduced synovial infiltration and bone destruction.
The T. chebula, T. belerica and E. officinalis extracts also showed a moderate dose-dependent scavenging effect of singlet oxygen species with IC50 values (Table 2) of 424.50 ± 24.70 μg/ml, 233.12 ± 48.68 μg/ml and 490.42 ± 159.59 μg/ml, respectively.
Abdominal pain (in up to 45% of patients) and flatulence were the most common adverse effects, being mild to moderate and dose dependent.
Dose dependent moderate to dark blue staining was observed for the exposure for 24 hr to 48 hr.
Generally, the colony densities ranged from slight to moderate (103 105 CFU), and it was dose dependent.
