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In addition, 38 (22.5%) had moderate disability, with a mean score of 14, and 40 (23.7%) had severe disability, with a mean score of 26 (Table 3).
The MIDAS scores showed that 13 (41.9 %) students had minimal disability with a mean score of 3. Five (16.1 %) students had mild disability with a mean score of 8. Six (19.3 %) had moderate disability with a mean score of 13, and finally, seven (22.5 %) had severe disability with a mean score of 25 (Table 3).
According to the scale classification, CPC1 is indicative for good cerebral performance; CPC2 implies moderate disability with sufficient cerebral functioning for independent daily-life activity; CPC3 indicates severe neurological sequelae; CPC4 implies coma or vegetative state; and CPC5 stands for death [23].
Overall, the cohort had moderate disease activity, with a median (IQR) DAS28 of 4.4 (3.4, 5.4), and moderate disability, with a median (IQR) HAQ disability index of 0.5 (0.1.41.4).
Results for the ODI confirmed moderate disability with 26.3 ± 8.1% (10 53%) for six months follow-up with further declining tendency to 20.5 ± 3.6% (6 30%) for final follow-up.
At analysis, physical function was further categorized as normal (without any difficulty); mild disability (with difficulty in at least one mobility task); moderate disability (with difficulty in both IADL and mobility tasks), and severe disability (with difficulty in ADL, IADL, and mobility tasks).
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Interestingly one study suggest a long-term placebo effect in chronic tension type headache in patients with a moderate disability or with a low initial anxio-depressive level, and in migraine patient with an optimal attack control.
Regarding MRS scores for subjects at baseline, 1% had no symptoms, 11.5% had no significant symptoms, 31.1% presented with slight disability, 32.5% presented with moderate disability, 15.6% presented with moderately severe disability and 7.8% presented with severe disability (Table 1).
In total, the average annual costs rose by €3347 for patients with severe disability, by €2206 with moderate disability, and by €2204 with mild disability, and by €1114 for patients with good functional capacity.
The performance categories are defined as follows: CPC 1, conscious and alert with normal function or only slight disability; CPC 2, conscious and alert with moderate disability; CPC 3, conscious with severe disability; CPC 4, comatose or in a persistent vegetative state; and CPC 5, certifiably brain dead or dead by traditional criteria.
At day 30 after infusion, nine patients (16.7%) were dead or in a vegetative state, twenty-seven (50.0%) with severe disability, two (3.7%) with moderate disability and sixteen (29.7%) with good recovery, according to the GOS-E assessment.
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