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There were 59 serous carcinomas and 3 cancers of other types; 5 tumours showed moderate differentiation (G2), 42 were poorly differentiated (G3), and 15 were mostly or completely undifferentiated (G4).
Histologically, 50 cases were well differentiated, while 10 cases were of moderate differentiation and 12 cases of poor differentiation.
The overall FST value was 0.1178, indicating a moderate differentiation among groups.
Moderate differentiation and frequent gene flow were detected among all populations (FST = 0.0659, P = 0000, Nm = 3.5436).
Moderate differentiation was detected among populations using RAPDs (30.80%), while only a small amount of variation (15.49%) was detected among populations using ISSRs.
Another example is 3-Deazaneplanocin A (DZNep), which has been shown to cause proteolytic degradation of PRC2 components, to influence histone modification patterns and to induce moderate differentiation effects in acute myeloid leukaemia cells [14] [17].
Temporally, moderate differentiation, 0.05 0.15 [70] with statistical support was observed in four comparisons (Table 3), and indicates differences between the Dec03 and Mar04 collections and 4 collections in or before July 2003.
Moderate differentiation: < 20% of the tumor islets has pearl formation.
Pleomorphism, moderate differentiation and loss of polarity in sebaceous glands were suggestive of metastatic invasion.
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While positivity for both molecules is maintained through carcinoma stage if PDAC retains well-to-moderate differentiation, poorly differentiated tumours tend to lose their expression.
Thus, including BAC component and well-to-moderate differentiation grade seem histological features of adenocarcinomas with EGFR mutations.
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