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Exact(7)
As selected by the inclusion criteria, in the control group none of the patients presented with severe diastolic dysfunction, but in 5/11 (45%) moderate diastolic dysfunction was present.
Redfield et al. [ 30] required two independent echocardiographic signs of at least moderate diastolic dysfunction to establish the diagnosis.
Henceforth, plasma BNP levels above 1.5 pmol/l indicates coexisting moderate diastolic dysfunction and further examination with echo would be warranted to further confirm this.
Isolated moderate diastolic dysfunction (ie, with LVEF >50%) was present in 17.3% (65/376), and isolated severe diastolic dysfunction in 2.7% (10/376).
LV diastolic dysfunction often precedes LV systolic dysfunction in heart diseases, and moderate diastolic dysfunction alone potentially induces heart failure, which is referred to as heart failure with preserved ejection fraction (HFpEF) [ 15].
In this study, we could demonstrate that natriuretic peptides do not accurately predict mild or moderate diastolic dysfunction, but are a very valuable tool to identify patients with severe diastolic dysfunction.
Similar(53)
Pseudonormal pattern (moderate LV diastolic dysfunction) was defined as E/A ratio of 0.75 to 1.5 and LV diastolic dominant pulmonary venous flow.
13 Moderate LV diastolic dysfunction was present in 25.0% (94/376) of participants and severe dysfunction in 5.9% (22/376).
Actually, BNP is a useful tool for screening preclinical moderate-severe diastolic dysfunction, which could be irrespective of age and obesity[25 26].
Moderate and severe diastolic dysfunction were considered present given an E/e′ ratio of 8 15 and >15, respectively [13].
Moderate and severe diastolic dysfunction is an indicator of advanced myocardial disease, is associated with clinical signs including exercise intolerance and congestive heart failure, affects outcome, and influences therapeutic decisions.
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