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Relevant control experiments revealed that extensive over-irradiation has only a moderate deleterious effect (entry 8), whereas deoxygenation is far more crucial (entry 9).
Furthermore, for neutral sites closely linked to selected ones, the loss of genetic diversity is even slower than expected from pedigree inbreeding, in agreement with previous findings by Wang et al. (1999), who also described slowed loss of neutral diversity under full sib mating in the presence of recessive alleles with moderate deleterious effect.
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The coral genome also encodes hypoxia-inducible factors (HIFs) that moderate the deleterious effects of hypoxia on cellular metabolism (reviewed in [ 270]).
It also investigated the extent to which two types of existential beliefs moderated the deleterious effects of perceived vulnerability on depressive symptoms and wellbeing.
Most of the mutations will be deleterious.
It evokes unpleasant images, and is always deleterious.
Let all mutations be deleterious.
The long-term effect is difficult to fully characterize, because the SSR is only a pre-deleterious allele and its impact on fitness will be only moderate unless the deleterious frame-shifted allele is extremely likely to appear and is associated with a strong impact on fitness.
Nutritionism by and large takes the Western diet as a given, seeking to moderate its most deleterious effects by isolating the bad nutrients in it — things like fat, sugar, salt — and encouraging the public and the food industry to limit them.
Recommendations were classified following a previously defined method as minor, moderate, major, extreme, deleterious or not applicable (description of classifications can be found in Table 4) [ 14, 28].
There is no evidence that moderate MAP increases have deleterious effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com