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Immunohistochemical analysis was performed to examine the expression of NGF, BDNF and their high-affinity receptors Trk-A and Trk-B in human IVD samples, divided into three categories: non-degenerate, moderate degeneration and severe degeneration.
For NGF, although a greater number of immunopositive cells were observed in the NP and IAF of disc samples of moderate degeneration and in the OAF of severely degenerate samples, these differences were not significant.
The proportions of immunopositive NP cells in each grade grouping (that is, 0 to 3 non-degenerate, 4 to 6 mild degeneration, 7 to 9 moderate degeneration and 10 to 12 severe degeneration) were counted and compared for statistical significance using the Mann-Whitney U test.
A grade of 0 to 3 indicates a histologically non-degenerate IVD, 4 to 7 indicates evidence of intermediate (or moderate) degeneration, and 8 to 12 indicates severe degeneration.
A section from portal triad area showed that periportal zone has a moderate degeneration while mild hyperemia was still retained in portal vein (Fig. 5b).
However, surgical NP samples showed significantly higher levels of MMP-10 immunopositivity than PM normal samples at grades 7 to 9 (moderate degeneration) and 10 to 12 (severe degeneration) (P < 0.05).
Similar(50)
Moderate albuminous degeneration, slight periacinar vacuolar degeneration, moderate diffuse congestion, and some hepatocytes with highly euchromatic nuclei or grayish cytoplasm were observed in the livers.
A lumbosacral spine x-ray showed age-related mild to moderate cartilage degeneration (Fig. 1).
It is indicated in degenerative spondylolisthesis with moderate disc degeneration and dynamic stenosis.
b There are moderate hepatocytic degeneration and necrosis, lymphocytic infilterate to Glisson's cupsule, hepatocytic balooning, and cholestasis in hepatocyte.
Histopathological examination demonstrated the presence of focal interstitial inflammatory changes, moderate tubular degeneration as well as interstitial fibrosis in some kidneys from the 72 clinically scrapie-affected sheep.
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