Sentence examples for moderate conformational changes from inspiring English sources

In response to simulated ion permeation, immediate hydration of the putative central pore was facilitated by moderate conformational changes of pore-lining residues.

Assuming moderate conformational changes and using grid approximation, the FFT based global and systematic sampling of the configurational space of two interacting proteins using a physics based energy function converts the docking problem into an exactly solvable problem of statistical mechanics (Kozakov et al., 2013).

It is likely that the conformational stability of small PrPSc aggregates is lower than that of larger ones (Weissmann et al, 2011), so that a moderate conformational change of a small seed, caused by thermal fluctuations, could come about and be 'fixed' as PrP (prion protein) accretion converted it into a larger, stable aggregate (Fig 1B).

The program is implemented in the heavily used server ClusPro (Comeau et al., 2007), which yields good results when docking X-ray structures of two proteins with at most moderate backbone conformational changes upon binding (Kozakov et al., 2010).

The high melting temperature (Tm = 352 ± 5 K), despite its moderate conformational stability, can be ascribed to its low heat capacity change upon unfolding, ΔCp, which had a value of 0.8 ± 0.1 kcal mol−1 K−1.

Its performance on unbound structures was only slightly lower, demonstrating that the method is insensitive to most ligand-induced conformational changes in the benchmark set, which include side-chain reorganization and small to moderate backbone changes.

So they undergo conformational changes.

Extended Data Fig. 4 R4 side chain conformational changes.

Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

Supplementary Figure 2 Conformational changes influence binding of ADI-15946.

Conformational changes drive protein function, including catalysis, allostery and signaling.