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and [1-C]acetylcarnitine (175 p.p.m., not quantifiable with moderate cardiac dysfunction and DCM).
Reperfusion after 150 min ischemia of the LAD leads to severe cardiac dysfunction and the development of heart failure over a limited period of time, whereas ischemia-reperfusion of the LCx culminates in stable, moderate cardiac dysfunction.
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Beyond infancy there is variable involvement of the heart in Pompe disease and a spectrum of disease among children with partial enzyme activity ranging from unaffected to moderate cardiac hypertrophy and cardiac dysfunction (personal communication, Carolyn Spencer, MD; Jami Levine, MD; Barry Byrne, MD PhD, 2005).
The second period (moderate) reflected a stage of subclinical cardiac dysfunction, and reported an average of data acquired after 2 5 weeks of pacing.
They demonstrated that overexpression of SIRT1 further promoted cardiac dysfunction, whereas Alcendor showed that moderate overexpression of SIRT1 rendered hearts resistant to oxidative stress-induced damage by paraquat.
Alcendor et al. [ 2] demonstrated that moderate overexpression of Sirt1 up to 7.5-fold attenuated age-dependent cardiac dysfunction and oxidative stress-induced apoptosis in mouse hearts, whereas a higher level (12.5-fold) of overexpression of Sirt1 increased apoptosis and hypertrophy and decreased cardiac function.
Patients with symptoms at rest or with minimal activity (moderate to severe heart failure) have a particularly poor long-term prognosis, with approximately half of these patients dying within two years from cardiac dysfunction or rhythm disturbances.
During this maneuver, cardiac dysfunction may occur.
ND [129],[130] LaTg2 Tg (αMHC) Baseline cardiac dysfunction.
Cardiac dysfunction is a common cause of weaning failure.
Cardiac dysfunction plays a critical role in weaning outcome.
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