PDE2a and PDE4d seemed to be the predominant isoforms specifically expressed in L-cells, with moderate but detectable levels of PDE1c, PDE3a, PDE8a, PDE8b and PDE11a mRNAs.
The "rare variant hypothesis" 5– 7 proposes that a significant proportion of the inherited susceptibility to relatively common human chronic diseases may be due to the cumulative effects of a series of low frequency dominantly and independently acting variants at different genes, each conferring a moderate, but detectable, increase in relative risk.
In contrast, CBS7960, DBVPG6040, GLBRCY0, IL-01, NC-02, PE-2, PW5, T7, UWOPS83-787.3, UWOPS87-2421 and YJM451 strains all displayed slow but detectable, moderate and fast growth rates in 9% ACSH, 6% ACSH and YEPD, respectively, at 40°C (Additional file 1: Table S1).
Responses from TRPA1 N855S were small but detectable using moderate doses of AITC (10 30 μM; Figure 5a).
The immunostaining intensities were categorized by the following scores: 0 (no staining), 1 (weak, but detectable staining), 2 (moderate staining), and 3 (intense staining).
The effect of NDGA on tumour growth observed in vivo was moderate but there was no toxicity detectable in the animals at the concentration used.
Initiation of vaccination campaigns in the presence of moderate levels of circulating pH1N1, but prior to the epidemic peak, had a modest but detectable impact on final attack rates.
For each core and each antigen, intensity of tumour staining was evaluated on a scale from 0 to 3 after the method by Allred et al (1998): 0, negative; 1, detectable but weak; 2, moderate but submaximal; or 3, maximal.
Almost every known chemical compound will dissolve in water to a small (but detectable) extent.
The 3′ terminal AU content makes modest, but detectable contributions.
Many people suspect that the tiny but detectable trend toward a Republican majority may deepen as county incomes rise.
