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Small absolute increases were seen in mild and moderate bleeding in patients given bivalirudin.
The other two moderate bleeding events were most probably related to the effect of heparin.
Three moderate bleeding complications in three patients, requiring three to four units of packed red blood cells, were observed.
Three moderate bleeding complications occurred requiring transfusions (3 to 4 units of packed cells), but none of the MARS runs had to be discontinued.
However, it is important to note, that this experimental model is similar to a "moderate" bleeding event, and animals were resuscitated within a relatively short period of time.
Three moderate bleeding complications, defined as significant bleeding events, occurred in three (9%) consecutive patients requiring more than two units (range three to four units) of packed red blood cells, one platelet concentrate and six to eight FFPs.
Similar(27)
This meant that children with signs of moderate inflammation (bleeding on probing), and moderate accumulation of plaque on tooth surface, and more were defined as children with poor oral hygiene.
Our bleed metric demonstrated good sensitivity and specificity at moderate bleed rates; area under receiver-operating characteristic curves were greater than 0.95 for bleed rates 20% and higher.
In this moderate bleeding-resuscitation animal model the volume-replacement ratio for crystalloids and colloids followed similar patterns as predicted by Starling's principle, and the glycocalyx remained intact.
The bleeding response was rated as good in 71% of patients with mild bleeds and in 42% of those with moderate bleeds.
Overall agreement between physician records and patient interviews was moderate for bleeding (κ, 0.55-0.58), forr for pain (κ, 0.29-0.34), and poor for impairment as a result of bleeding or pain (κ, 0.0-0.14).
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