These results are consistent with those of Weiss et al. [45], who reported that transposon mutagenesis of F. novicida FTN_1213 (equivalent to FTL_1423 of LVS) resulted in moderate attenuation following subcutaneous challenge of mice.
In addition to moderate attenuation (75% over 17 years), we considered no attenuation and rapid attenuation (75% over 6 years).
Despite the fact that pioglitazone significantly attenuated the total number of cells lavaged in the BAL, only a moderate attenuation of the mononuclear cells (p = 0.073) and neutrophils (p = 0.063) was observed.
Seismicity in the upper crust and earthquakes with M ≥ 6.5 (white stars in Fig. 4) tend to occur in areas of low to moderate attenuation.
Moderate attenuation (0.2 < CI < 0.4) was seen in Δ spr0991 (short chains, partially defective autolysis) and Δ spr2028 (long chains, no defective autolysis).
MSP68 effectively inhibits excessive neutrophils infiltrating to organs, leading to moderate attenuation of organ injury and significantly improved survival in septic mice.
There was moderate attenuation of the β coefficient after adjustment for antidepressants in this study.
In DZSS twins, a minor or moderate attenuation could be observed, and all effect parameters were statistically significant, except for ATC-C drugs.
Most other quantitative variables had RDRs in the range 0.66-0.86, consistent with slight to moderate attenuation, with the exceptions of age at menarche (RDR = 0.44, 0.33-0.55), birth weight (0.59, 0.50-0.67) and waist-to-hip ratio (0.50, 0.35-0.66), for which more substantial attenuation is likely.
Comparing the fold changes of genes in WT and sak1 during acclimation, we defined 104 genes as SAK1-dependent genes that displayed moderate to strong attenuation in their response (fold change ratio <0.5) (Table 5).
