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Treatment-induced toxicity was moderate and reversible in all patients.
The reactive metabolite of acetaminophen, N-acetyl-p-benzo-quinoneimine (NAPQI), is able to activate the TRPA1 channel and thereby evoke a moderate and reversible neurogenic inflammatory response, which, in susceptible individuals, may contribute to emphasizing inflammation in peripheral tissues [76].
The severity was on average mild to moderate and reversible.
Adverse events were mainly gastrointestinal and the severity was on average mild to moderate and reversible.
In our pediatric patients, we observed a significant but moderate and reversible increase in the liver parameters ALT and AST.
Toxicity was moderate and reversible and consisted mainly of fever, flu-like symptoms, nausea, weight loss and hepatotoxicity.
Similar(51)
Most treatment-emergent AEs were mild-moderate and reversible, commonly including nausea, diarrhoea, vomiting, constipation, fatigue, and anaemia (CP-868,596/docetaxel), and hypertension, lethargy, diarrhoea, and fatigue (CP-868,596/docetaxel/axitnib).
An interesting cooperative effect is shown for the Au-CuOx/CeO2 catalyst: (i) moderate and totally reversible inhibition by CO2 and (ii) absence of inhibition by steam.
Apart from anaphylactic reactions in two patients and grade 3 peripheral neurotoxicity in six, nonhaematologic adverse reactions were generally mild to moderate and fully reversible.
These events were generally mild-to-moderate in intensity and reversible.
3, 4, 7– 9 In clinical trials, most of these irAEs were mild to moderate, and most were reversible using a set of treatment guidelines that were developed for ipilimumab based on clinical experience with the drug.
More suggestions(15)
modest and reversible
moderate and Clintonite
moderate and cosmopolitan
moderate and modern
moderate and sound
moderate and loud
moderate and subdued
moderate and respectable
moderate and occasional
moderate and centrist
moderate and tolerant
moderate and independent
moderate and unpredictable
moderate and conservative
moderate and willing
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