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All compounds displayed moderate affinity for 5-HT1A receptor.
Acid-leveling dyes: These dyes are smaller or medium sized, and show a moderate affinity for wool fibers.
Usually, they primarily have high affinity for somatostatin receptor subtype 2 (sst2), and they have moderate affinity for sst5.
Several high-throughput screenings in the past have found candidate ligands showing a moderate affinity for GALK.
To address these two major problems, we designed the 2-pyridone-based lead 15a, which showed moderate affinity for CB2.
Finally, it is noteworthy that DHE also displays moderate affinity for other receptors, including the 5-ht1E (pK i : 6.2) subtype (Table 1).
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All compounds exhibited significant to moderate affinities for 5-HT1A receptors in nanomolar range (7 610 nM).
Flavonoids display moderate affinities for albumins with binding constants in the range of 1 15×104 M−1 15×104
Previously, we reported that some SSRIs possess high to moderate affinities for sigma-1 receptors in the rat brain.
Lurasidone can be differentiated from other available second-generation atypical antipsychotics by its receptor binding profile, with moderate affinities for the serotonin 5-HT7, noradrenaline α2c (antagonist), and serotonin 5-HT1A (weak-moderate pagonistagonint), in addition to the expected high affinity binding for dopamine D2 and serotonin 5-HT2A receptors.
The moderate affinity of Hox3 for Xlox in our analyses may be due to convergence or it may represent a bilaterian-specific duplication.
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