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The synthesized molecules showed good to moderate activity with MIC in the range of 5 150 μM and good safety profile.
Four compounds were ineffective with MIC >256 μg/ml (highest concentration tested), six exhibited poor activity with MIC > 100 μg/ml, four showed moderate activity with MIC > 50 μg/ml and two had notable anti-TB activity with MIC values 32 μg/ml.
However, B. cereus and L. monocytogenes showed moderate activity with MIC values of 65 μg/ml.
Methanol, chloroform, ethyl acetate and n-butanolic fractions of root exhibited moderate activity with maximum activity given by n-butanolic fraction against B. cereus.
The methanol, n-hexane, chloroform and ethyl acetate fractions of leaves showed moderate activity with considerable value shown by chloroform fraction (12 mm).
Against M. luteus, compounds 4 and 7 demonstrated a moderate activity with MIC 125 and 500 μg/mL, respectively but failed to show appreciable activity against P. aeruginosa.
Similar(42)
In vitro evaluation of the new series for calcium channel blocking effects revealed moderate activities with IC50 values in the range of 4.8 56.0 μM.
Some crude extracts of different parts of the plant displayed either weak or moderate activities with inhibition zones between 6 and 13 mm.
Although O2− and H2O2 elicit moderate activities with other biological molecules, the end product of their reaction generates hydroxyl radical (·OH), which is highly reactive, and accounts for most of the oxidative damages attributed to ROS.
The methanol extract of P. nitida leaves and the hydroethanol extract of S. oleraceus showed moderate activities with IC50s of 0.24 ± 0.03 and 0.28 ± 0.04 mg/mL, respectively, whereas the stem bark of P. nitida had the lowest activity (IC50 = 1 mg/mL).
During the three iterative web-based blinded evaluation sessions, consensus was achieved on 63/106 cases (59.4%), with 13 patients declared as inactive, 49 as active (26 with low activity, 13 with moderate activity, 10 with high activity), and one patient was not evaluable (wrong diagnosis) by consensus.
More suggestions(14)
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