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Unfortunately, SPIO measurements are insensitive to early and moderate abnormalities.
Of these, 13 infants were clinically diagnosed with mild to moderate abnormalities, one with severe, and six with no abnormalities on conventional MRI by a neuroradiologist.
Of the 10 new ELBW infants' MRI scans used to determine tissue segmentation accuracy, seven were diagnosed with mild to moderate abnormalities, one with severe, and two had no reported abnormalities.
Brainstem evoked potentials showed moderate abnormalities.
Importantly, a policy of selective referral to coronary angiography based upon high-risk findings is defensible, patients with mild to moderate abnormalities managed medically having outcomes comparable to those undergoing invasive evaluation and subsequent angioplasty [ 133].
Although airway obstruction is not a characteristic of ALI, patients who survive ARDS can present mild to moderate abnormalities in lung function evidenced by decreased FEV1, FVC and/or FEV1/FVC evaluated one to three years after hospital discharge [ 35- 37].
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A minor neurological dysfunction is defined as a moderate abnormality of tone, posture, and movement leading to only minor functional impairment or a minor developmental delay.
Moderate abnormality showed excess slow activity of similar amplitude to the ongoing activity, present for <50% of the recording, with definite evidence of age appropriate activity.
Our cutoff values between normality, mild and moderate abnormality and severe abnormality are similar to recent studies on large populations of both normal controls [ 18, 19] and patients with cardiac dysfunction [ 25].
Furthermore, in this study, remarkably higher levels of Hg and Pb were recorded in patients with severe social and cognition impairment (SRS & CARS) compared with those with mild-moderate abnormalities.
All participants had mild to moderate lipid abnormalities.
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