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As a member of the proneural subclass of bHLH factors, emerging models would place low Ascl1 activity at early stages to give tone to Notch-regulated progenitor maintenance [17].
These models would place OCRL upstream of SNX9.
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The main assumption is that a better model would place more participants at the extremes of the risk distribution, with the upper category having clear implications for preventive interventions.
In the amphipathic helix-loop model, this would place CENP-T on the inside, in direct contradiction with the dual-label microscopy mapping measurements.
Furthermore the schematic presented in Figure 4D implies that the coiled-coil of CENP-HK runs parallel to the outside surface of CENP-I (which is convex in the model) and would place the axis of the coiled-coil at right angles to the axis of the HEAT repeat, which seems unlikely (and also would probably not fit into the EM reconstruction as suggested in supplemental figure 4).
Current models for mammary differentiation would place this cell at a late point in the hierarchy, after the luminal progenitor stage [ 54].
Because the N-terminus of the RyR is cytosolic (179), the limited information provided in the original publication (173), namely that the epitope lies between TMD6 and TMD7 of the originally proposed 10-TMD model of RyR (180), would place the epitope within the cytosol.
All docking models on full-length Uba2 would place Ubc9's catalytic cysteine distal to and facing the opposite direction of Uba2's catalytic cysteine (Figure 4A).
Subsequent work revealed that Ab was raised to residues 4676−4699 of rabbit RyR2 (181), and the revised six-TMD models of RyR (167, 179) would place the sequence between TMD2 and TMD3 (181), which again places the epitope within the cytosol.
Note that a classification model built from this projection would place P54 into a good or poor prognosis class despite the missing information.
As they note, this would place the 32GB model at the same price point as competitor's 16GB model.
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