The investigation is performed on synthetic models with variation of q in the interval from 30 to 0.001.
Model simplification was based on an analysis of the factors affecting survival and resighting probabilities and constructed models with variation between age and time, and the age*time interaction.
Simulation of the models with variation of their sequestration strength revealed that feedback loop from Phos2 to MKKK-P could be abolished in both M4K1 and M4K2 by increasing the phosphatase sequestration strengths.
Part II of the paper reports the experimental validation of the LSSE LSPP model and a study of the sensitivity of the model with variations in the model parameters.
In this approach, sets of many simulations of the same model with variations in parameters representative of cell-to-cell variability sources (the sources of this variability are discussed in the next section) are used to approximate the behavior of an ensemble of cells.
A polygenic model with variations in several loci, each contributing a modest independent risk has been shown to best explain the residual non BRCA1/2 aggregation of breast cancer, and the effect of low penetrant genes may also at least partly explain sporadic breast cancer [ 2, 3].
Because we expected the geographic isolation and ecological context of each subpopulation to play a large role in shaping niche variation among individuals [14], we considered models with regional variation alone, pack variation nested within region, and regional variation in diet with residual errors on the consumer isotope signatures.
Variations in exposure were mostly attributable to spatial rather than temporal variations in both models, with temporal variation making a larger overall contribution to total variation in the TAG model than in the nearest-AQMS model.
MSM, MSMH, MSI, MSIH, MSIA, and MSIAH implies a Markov switching model with variation in mean, mean and variance, intercept, intercept and variance, intercept and autoregressive parameters, and intercept, parameters, and variance, respectively ***, **, *Denotes significance at the 1, 5, and 10%, respectively.
