Sentence examples for models with transgenic from inspiring English sources

In order to study eventual beneficial effects, crosses of existing transgenic AD models with transgenic mice overexpressing Rer1p may be considered.

Future studies directed towards the identified ECM constituents using cell lines in vitro as well as hepatic injury models with transgenic animals will be needed to elucidate further the microenvironment governing an HPC response.

Recently, it was shown that ROS production was reduced in a T1DM and T2DM mouse models with transgenic overexpression of the anti-oxidant enzyme catalase in proximal tubular cells [ 59, 60].

To understand how the SCF E3 ligases regulate these cellular processes and embryonic development under in vivo physiological conditions, a number of mouse models with transgenic (Tg) expression or targeted deletion of components of SCF have been established and characterized.

We here report the establishment and initial characterization of a mouse model with transgenic expression of human acute phase SAA in adipocytes under the control of the aP2 enhancer/promoter.

In an additional study the desmin knockout strain was crossbred with another desmin mouse model with transgenic expression of the p.Ile451Met mutant [ 113].

It is interesting to compare our findings with those in a murine model with transgenic overexpression of a comparable truncated TNNT2 protein under the control of the alphaMHC myh6) promoter (Tardiff et al., 1998).

Therefore, the role of the H4R on Th17 cell development in vivo was directly assessed using an adoptive transfer model with transgenic OT-II T cells specific for ovalbumin.

To gain a better understanding adult muscle build-up and its associated energy metabolism, we employed a mouse model with transgenic expression of myostatin propeptide and dramatic muscle growth.

Contrary to previous studies suggesting a pro-fibrotic role, two contrasting studies, one using a fibrosis model with transgenic mice expressing IL-13 (Lanone et al., 2002) and the other a model involving radiation injury followed by bone-marrow transfer (so-called 'RAD+BMT') (England et al., 2011), observed either no effect or an anti-fibrotic effect of MMP-12, respectively.

We now have generated a mouse model with transgenic over-expression of the mitochondrial protein frataxin to address our hypothesis that constitutive activation of mitochondrial energy metabolism might reduce the incidence of experimental CF. We employed doxorubicin (DOX), also used as an anticancer drug in human medicine, to induce experimental cardio-myopathy.