Efforts are made to design a relatively simple model as compared to the high complexity of the experiments, applying simple mathematical sub-models with straightforward interpretations and enabling a numerically stable implementation.
It is simply fascinating how something so complex, something with moving parts that can adapt and change through time, can all be modeled with straightforward graphs that have all been introduced within this class.
Alternatively, the first two steps of the novel procedure can be used as a tool to demonstrate clearly (possible) interpolative shortcomings of an existing model with straightforward spreadsheet calculations.
All models are parameterized with straightforward engineering data.
In this, FCA can be considered as a "white box" model with a straightforward interpretation.
When fewer than five samples yielded undetectable metabolite levels, the logistic regression component of the mixture model was eliminated, yielding results consistent with straightforward linear models.
Five variants of this readmission model are considered (all with straightforward modifications to the likelihood): In model III, patients who are not colonized at discharge are assumed to have the same phase-independent probability, ν, of being colonized on subsequent readmissions as patients with no previous documented admissions.
The statistical treatment of linear Gaussian unobserved components models is straightforward, with the Kalman filter playing a key role.
While mechanistic modeling provides a powerful lens, empirical PK/PD modeling will still remain a valuable approach to quantifying the concentration effect relationship of ECG intervals from both the clinical and preclinical studies in the near future, because it is an effective way to assess CV safety risk and the models are straightforward to implement with little mechanistic understanding.
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First, it would be tedious but straightforward to consider models with more than two components after dealing with identification issues.
