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With the horizontal grid of a catwalk, and stripes often repeated in the clothes, the impression was of a seaside boardwalk circa 1960, the models with smooth beehives and a dainty way of walking on their colored (and stripy) sandals.
Topology-based models with smooth energy landscapes give reasonable predictions of the structure of the transition state ensemble, but do not have the kinetic or thermodynamic cooperativity exhibited by two-state proteins.
Accordingly, we believe that, using continuation methods, these results and, more generally, results on generation of traveling waves in unidirectional chains of type-I oscillators can be established in a rigorous mathematical way, in more general models with smooth PRC and stimulus nonlinearities.
Furthermore, observed and unobserved confounding factors can be controlled for by the use of Poisson regression models with smooth functions for confounding variables.
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We tested the effect of different lag times on NHL risk through analysis of deviance (ANODEV), testing for significant differences between model deviances from the model with no smoothing term and from the five models with smoothing terms (one for time at diagnosis, four with lag times).
This construction tends to generate candidate models with smoother small scales compared to mathematical models providing candidates as snapshots at a given epoch.
Additive models with smoothed terms for exposure were also estimated to assess the nature of the association between lead exposure and BP.
Linear models were compared with additive models with smoothing splines using the generalized additive model (GAM) function in the MGCV R package (http://www.R-project.org) and linearity was confirmed.
For the basic model, we used natural cubic spline models with smoothing for time and weather, using R software (version 2.5 with mgcv 1.3 24; R Development Core Team 2007).
Linear mixed effects models with smoothing splines were used for longitudinal modelling of BMD and its components bone mineral content (BMC) and bone area (BA), from 9 to 17 years.
Cox proportional hazards regression models with smoothing splines 20 were used to plot the relationship between each biomarker's levels and mortality (quantified as relative hazard) after adjusting for age, gender, race, income, and body mass index (BMI) (Fig. 1A C).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com