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There is a variety of tracking methods including Active Shape Models with Point Distribution Model [22, 37, 38], Constrained Local Models [39], deformable part-based models [40], subclass divisions [41] and appearance-based facial features detection [42].
Here, we review how CRISPR-Cas9 has been used to create germline and somatic mouse models with point mutations, deletions and complex chromosomal rearrangements.
We calculated linear regression models with point in time as independent variable and average age of reported cases as dependent variable.
However, because with this data set the number of parameters (betas and thresholds) to be estimated is high, we compared both models with point and interval estimates of the probabilities estimated for each category on the four- and five-point ordinal scale for each data set studied.
These phenotypes are shared by other intermediate SMA models with point mutations (Smn2B/− mice) or exon deletions (SmnF7/Δ7, NSE-Cre mice) in murine Smn, although these strains lack an SMN2 transgene, which is being actively pursued as a therapeutic target in human SMA (Park et al, 2010a).
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Plots of residuals versus predicted values from each model further confirms adequacy of both models, with points scattering around zero and no obvious linearity or curvature (Fig. 2c d).
This code is based on a 1-D node junction model with point kinetics and decay heat calculations.
The ALFRED core mathematical model developed in this work is fully transient, which takes into account the heat transfer in an annular fuel pellet design, the thermo-fluid in the core, and the neutronic processes, which are modeled with point kinetic with feedback fuel temperature and expansion effects.
Individual covariates were entered and removed from the model with point estimates and model performance was evaluated with each step [ 19].
Finally, model performance evaluated against monitoring data is always affected by the issue of comparing areal predictions by the model with point measurements.
To evaluate the treatment effect (mean difference in KOOS scores) we will employ a random or fixed effects linear regression model with point estimates [ 62] and both crude and adjusted results will be reported.
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