Sentence examples for models with mutant from inspiring English sources
However, there was considerable variability in levels of expression for models with mutant p53.
Taken together, these results support a novel mechanism for Tau protein transfer compared to previous reports based on transgenic models with mutant cDNA.
In fact, we found that activation of the PI3K pathway in our three ER+/HER2- cell models with mutant PIK3CA, was substantially enhanced upon PTEN-KD.
Our cell line models with mutant PTEN and overexpression of EGFR and/or p53DD that transform MCF10A cells can serve as a foundation for identifying additional driver insults (epigenetic and/or genetic) capable of making the cells more transformed and tumorigenic in mice.
When we compare our model with mutant CAs, such as the T199A mutant [where the hydrogen bond to the Zn II -coordinating solvent molecule has been removed], little to no difference in efficiency is observed.
This is confirmed statistically using a Poisson general linear model with mutant count per locus as the response variable, motif type as a categorical factor, and progenitor repeat number as the covariate.
Going beyond these conclusions, we then make use of independent verifications, such as a comparison of our models' predictions with mutant and misexpression data.
Finally, activators of PI3K, including epigallocatechin gallate, have been shown to increase cell survival in cellular models transfected with mutant SOD1 (Koh et al., 2004, 2005) and treatment of the G93A SOD1 mice with epigallocatechin gallate significantly delayed the onset of disease, and extended life span (Xu et al., 2006).
Two mouse models with different mutant Crb1 alleles exist (13, 16).
35, 36 In vivo models confirmed the cellular selectivity of vemurafenib; in melanoma cell lines and xenograft models with V600E mutant BRAF, including Colo829, LOX, and A375, vemurafenib rapidly suppressed ERK signaling and hence tumor cell proliferation and survival, but lacked activity or conferred a growth advantage in wild-type BRAF melanoma cell lines.
The original intent of this study was to create a genetically modified mouse model in with mutant oncogenic K-RasG12D would be conditionally expressed following the activation of Cre:ER protein by topical 4HT administration.
