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Mouse models with loss of LMNA function have reduced Retinoblastoma protein (RB1) activity, leading to aberrant cell cycle control in interphase, but how mitosis is affected by LMNA is not well understood.

Mouse models with loss- or gain-of-function mutations in the osteocalcin gene (BGLAP) suggested that osteocalcin is responsible for the regulation of fertility in males only [ 36].

Possible predictors of cortical hand bone loss were also examined using univariate logistic regression models with loss in cortical hand bone exceeding LSC as the dependent variable.

Therefore, we repeated all analyses using drop-out weights for each participant derived from logistic regression models with loss to follow-up as an outcome variable.

Neuregulin 1 (NRG1) and the γ-secretase subunit APH1B have been previously implicated as genetic risk factors for schizophrenia and schizophrenia relevant deficits have been observed in rodent models with loss of function mutations in either gene.

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This discovery followed other mouse models with loss-of-function IKKα alleles that developed papillomas and skin SCC (Liu et al., 2012).

Second, because many published algorithms do not include losses in the optimization criterion (e.g., Berglund et al., 2006; Ma et al., 2000; Tofigh et al., 2011; Zmasek and Eddy, 2001), we compared models with losses (DTLI, DTL) and without losses (DTI, DT).

A substantial body of recent work has documented loss of mitotic fidelity in cellular models with RB1 loss (Manning and Dyson, 2012) and loss of mitotic fidelity is well suited to explain the development of chromosomal aneuploidy seen in retinoblastoma tumors.

In addition, no naturally occurring mouse models associated with loss of other DGC components are available.

During the preliminary design stage, the critical parameters of the engine design are determined according to the dynamic model with losses energy and pressure drop in heat exchangers was used during the design optimisation stage in order to establish a complete analytical model for the engine.

Hence, we study as well how to cope with the computation of nonlinear models with no loss of efficiency.

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